direct or control; projects, businesses, etc.; "She is running a relief operation in the Sudan"
perform as expected when applied; "The washing machine won't go unless it's plugged in"; "Does this old car still run well?"; "This old radio doesn't work anymore"
handle and cause to function; "do not operate machinery after imbibing alcohol"; "control the lever"
perform a movement in military or naval tactics in order to secure an advantage in attack or defense
keep engaged; "engaged the gears"
perform surgery on; "The doctors operated on the patient but failed to save his life"